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M9480427.TXT
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1994-08-20
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Document 0427
DOCN M9480427
TI Splenic rupture in hemophilia.
DT 9410
AU Fort DW; Bernini JC; Johnson A; Cochran CJ; Buchanan GR; Department of
Pediatrics, University of Texas Southwestern; Medical Center, Dallas.
SO Am J Pediatr Hematol Oncol. 1994 Aug;16(3):255-9. Unique Identifier :
AIDSLINE MED/94311464
AB PURPOSE: Little information is available regarding splenic injury in
patients with hemophilia. We describe here the management of splenic
rupture in five of our patients with hemophilia and summarize the
literature describing this complication. PATIENTS AND METHODS: Two human
immunodeficiency virus-seropositive patients were managed medically and
did not require splenectomy. A third patient had a high titer inhibitor
to both porcine and human factor VIII and required emergency
splenectomy. Two boys had not been previously diagnosed with hemophilia
until they underwent splenectomy after abdominal trauma. RESULTS: All
five patients survived. CONCLUSIONS: These cases demonstrate that
nonsurgical management of splenic injury in patients with hemophilia can
be performed safely and that splenectomy can be successfully performed
despite a high titer of factor VIII inhibitor.
DE Adolescence Case Report Child Child, Preschool
Hemophilia/*COMPLICATIONS Human Male Splenic
Rupture/*ETIOLOGY/THERAPY Support, Non-U.S. Gov't Support, U.S. Gov't,
P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).